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Marion B. Sulzberger, M.D.; Victor H. Witten, M.D.; C. Conrad Smith, M.D.
JAMA. 1953;152(15):1456. doi:10.1001/jama.1953.03690150060022.
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To the Editor:  —In a recent article in The Journal (151:468 [Feb. 7] 1953), we reported that the topical application of hydrocortisone acetate ointment was of value in the treatment of particular diseases of the skin. Our conclusions were drawn after comparing the effects of hydrocortisone acetate in various ointments applied to the affected areas of one side of the body with the effects of the respective ointment base, without hydrocortisone acetate, applied as a control to symmetrically situated affected sites. Observations on 62 patients were included in our first report.Because oral administration of the free alcohol is more effective than administration of hydrocortisone acetate, we thought it important that ointments incorporating the free alcohol be compared with ointments containing the acetate. The clinical evaluation of the therapeutic effectiveness of the hydrocortisone free alcohol ointment was accomplished by comparing it with the hydrocortisone acetate ointment (incorporated in the


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