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Paul Getzoff, M.D.; John Hidalgo, M.S.; Joe Meyer, Ph.D.
JAMA. 1953;152(15):1431-1432. doi:10.1001/jama.1953.63690150005009d.
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Since the introduction by Flocks and others1 of the concept and technique of employing radioactive gold (AU198) in the treatment of prostatic carcinoma, we have been interested in this fresh approach and the promising results obtained. We have found Flocks' operative method completely satisfactory. The technique for concentrating a solution of radioactive gold in the prostate gland consists of the direct injection of the material into the organ suprapubically, retropubically, and through a spinal needle inserted perineally. Obviously, certain problems are involved with any method that includes use of radioactive isotopes.

The broad principles involved in this operation may be briefly summarized as follows: 1. The radioactive gold must be injected in such a manner as to assure maximum diffusion of the solution throughout the prostate gland. 2. Retrograde leakage through the tract produced by the needle should be minimal. 3. Depth of the injection must be completely


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