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Tracy J. Putnam, M.D.; Sanford F. Rothenberg, M.D.
JAMA. 1953;152(15):1400-1406. doi:10.1001/jama.1953.03690150004002.
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The years 1935 to 1939 at the neurological unit of the Boston City Hospital witnessed the beginning of a revolution in the understanding and control of epilepsy. In this clinic, then under the supervision of one of us (T. J. P.), electroencephalography for the first time became a routine clinical service, and its special value in the field of convulsive disorders was demonstrated.1 The resultant knowledge was utilized to study the effects of various drugs and physiological states on cerebral dysrhythmia.2 Against this background, one of us (T. J. P.) formulated the conception of a series of specific anticonvulsant drugs, suggested a molecular configuration that has since proved highly successful in several variations, and set up a simple, reliable method of testing the effects of such drugs in animals.3 The significance of these suggestions and of the theoretical considerations and administrative manipulations that later led to the


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