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Bernhard Dattner, M.D.; Evan W. Thomas, M.D.; Lopo de Mello, M.D.
JAMA. 1949;141(17):1260. doi:10.1001/jama.1949.02910170062022.
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To the Editor:—  We have read with grave concern the article on the treatment of neurosyphilis by Dr. Douglas Goldman in The Journal, Oct. 15, 1949. Although there is some controversy about the exclusive use of penicillin in the treatment of neurosyphilis, there is almost unanimous agreement among the experts in this field that the intrathecal injection of penicillin is unnecessary and even dangerous. Severe reactions with this type of treatment have been reported in the literature, and we believe that it is a mistake to give the medical profession the impression that intrathecal therapy is desirable for neurosyphilis. In addition, Dr. Goldman provides no control data on patients treated exclusively by intramuscular injections with penicillin.At Bellevue Hospital, New York, since the early part of 1944 we have treated more than 500 patients with neurosyphilis with penicillin alone. In our experience as well as that of numerous other investigators


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