April 15, 1939, Vol 112, No. 15 >

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THE INFLUENCE OF MALARIAL INFECTIONS ON THE WASSERMANN AND KAHN REACTIONS

S. F. KITCHEN, M.D.; E. L. WEBB; W. H. KUPPER, M.D.

JAMA. 1939;112(15):1443-1449. doi:10.1001/jama.1939.02800150015005.

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Many contradictory opinions and results regarding the ability of malaria to provoke nonspecific, positive reactions with both the complement fixation and the flocculation test for syphilis have found their way into the literature. Lloyd and Mitra¹ summarized the reports on the question of falsely positive reactions which had been published up to the time they wrote, and they added data on eighty-five cases of their own. They believe that there is no evidence that malaria causes positive serologic reactions with modern technics. In a subsequent publication the senior author² of the former paper expressed the opinion that "the occurrence of positive reactions in malaria is partly a question of technic and partly a question of concomitant syphilis... it is only with very sensitive technics that a positive Wassermann will be obtained in malaria and even then the reaction is weak..." Kolmer³ stated that in his experience malaria,

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KITCHEN SF, WEBB EL, KUPPER WH. THE INFLUENCE OF MALARIAL INFECTIONS ON THE WASSERMANN AND KAHN REACTIONS. JAMA. 1939;112(15):1443-1449. doi:10.1001/jama.1939.02800150015005.

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