0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

Clinical Notes, Suggestions and New Instruments

JAMA. 1946;131(11):893-894. doi:10.1001/jama.1946.02870280019006.
Text Size: A A A
Published online

AGRANULOCYTOSIS INDUCED BY AMINOPYRINE SUPPOSITORIES 

Recovery Following the Use of Penicillin in a Highly Allergic Individual  ERICH URBACH, M.D. and HAROLD L. GOLDBURGH, M.D. PhiladelphiaAgranulocytosis caused by aminopyrine is well established both clinically and experimentally.1 However, there seem to be no instances reported of agranulocytosis caused by aminopyrine administered by the rectal route. Dameshek and Wolfson2 have stated that death in agranulocytosis is probably the result of overwhelming sepsis in a body stripped of its granulocytic defenses.In our patient the use of penicillin seemed logical to control such sepsis until spontaneous recovery of the function of the bone marrow might occur, especially since penicillin does not cause any depression of the bone marrow, as is not infrequently seen with the sulfonamides. In addition to the beneficial effect of penicillin, our purpose in this communication is to point to a possible allergic mechanism in this particular case by which aminopyrine probably acted as a hapten and altered tissue protein as a protein carrier.

REPORT OF CASE  A white woman aged 43 suffered

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();