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CANCER OF ENDOMETRIUM AND PROLONGED ESTROGEN THERAPY

MAURICE FREMONT-SMITH, M.D.; JOE V. MEIGS, M.D.; RUTH M. GRAHAM, B.S.; HELEN H. GILBERT, A.B.
JAMA. 1946;131(10):805-808. doi:10.1001/jama.1946.02870270005002.
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Estrogenic substance is today prescribed for a host of gynecologic complaints. It is given for the control of menorrhagia, amenorrhea and dysmenorrhea, for premenstrual headaches and depression, for asthma, for arthritis and for osteoporosis. Symptoms associated with the climacterium are in some clinics treated almost continuously and over periods of years with estrogenic substance. The prescription of estrogen is unfortunately not always preceded by a pelvic examination. Thus it has been given to patients with unrecognized uterine cancer1 and prescribed for amenorrhea in the congenital absence of a uterus and vagina.2 Criticism of the indiscriminate use of estrogenic substance has appeared in the literature, and fears have been expressed as to its possible carcinogenic effect on the breast and uterus.3

REPORT OF CASE  The subject of this report was treated with large amounts of estrogenic substance almost continuously over an eight year period. At the end of

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