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TREATMENT OF PNEUMOCOCCIC PNEUMONIA WITH SULFANILAMIDE

ALVIN E. PRICE, M.D.; GORDON B. MYERS, M.D.

JAMA. 1939;112(11):1021-1027. doi:10.1001/jama.1939.02800110001001.

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Sulfanilamide has proved bacteriostatic against types I, II, III and XIV pneumococci in vitro and in laboratory animals, according to various authors.¹ While the drug probably has been used widely for human pneumococcic pneumonia, the reports to date are meager. Heintzelman, Hadley and Mellon² used it in nine cases of type III pneumonia and obtained seven recoveries, whereas among ten controls there were only two recoveries. Millett³ reported one case of type III pneumonia in which a crisis occurred after the use of sulfanilamide. Louis⁴ added six cases of pneumococcic pneumonia in which recovery occurred with sulfanilamide therapy.

The following report is based on 115 patients treated with sulfanilamide.⁵ compared with forty patients receiving serum and ninety-four controls receiving identical symptomatic and supportive measures but no specific therapy. While this series is too small to be statistically significant, it is reported in the hope that

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PRICE AE, MYERS GB. TREATMENT OF PNEUMOCOCCIC PNEUMONIA WITH SULFANILAMIDE. JAMA. 1939;112(11):1021-1027. doi:10.1001/jama.1939.02800110001001.

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