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November 12, 1949, Vol 141, No. 11 >

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JAMA. 1949;141(11):781-782. doi:10.1001/jama.1949.02910110033014.
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INSULIN AND TISSUE PROTEIN  The metabolism of protein is influenced by the metabolism of carbohydrate. After the discovery of insulin, Janney1 conducted experiments from which he could show insulin causes a decrease in the urinary nitrogen. He suggested, "It seems possible that carbohydrate metabolites are synthesized into the protein molecule by the aid of insulin." At the same time, Weichmann2 demonstrated in normal and diabetic subjects that insulin effects a decrease in the amino acid nitrogen of venous blood. The depressing effect of insulin on the amino acid level of the blood was confirmed in man and in the rat, rabbit and dog.3 Because of the role of the liver in protein metabolism, this organ might be assumed to be implicated in the foregoing phenomenon. However, using eviscerated animals, Mirsky4 showed that the amino acid level of the blood remains normal for long periods following the

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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