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GALLSTONES IN LOWER ANIMALS

JAMA. 1932;99(15):1266. doi:10.1001/jama.1932.02740670054018.
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Some time ago it was pointed out in The Journal1 that there is a striking difference between man and the ordinary laboratory animals as far as the occurrence of gallstones is concerned. The point was made, furthermore, that experimental attempts to produce cholelithiasis in these species had been uniformly futile up to that time and that this failure had retarded progress in clarifying the etiology of gallstone formation in human patients. The question of difference in the physiology of the biliary apparatus still commands considerable interest. As the gallbladder of certain species of mammals does not empty after food is taken, a recent study of Boyden2 is worthy of comment. He employed monkeys (Macacus rhesus) and in three normal males observed extremely rapid evacuation of the gallbladder after a meal rich in fat. The first animal emptied three fourths of the contents of the viscus in thirty-six minutes,

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