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November 12, 1949, Vol 141, No. 11 >
Other Articles | November 12, 1949

JAUNDICE

PHILIP THOREK, M.D.
JAMA. 1949;141(11):767-771. doi:10.1001/jama.1949.02910110019006.
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ABSTRACT

Jaundice, or hyperbilirubinemia, is an important subject to both the general practitioner and specialist; it always presents an interesting diagnostic problem. To have ways and means of coordinating and simplifying the subject is imperative, so that with the diagnostic armamentarium at hand a diagnosis may be readily reached and proper therapy instituted. A thorough knowledge of the pathologic physiology involved results in a more rapid and accurate diagnosis than does the memorized knowledge of the hundred and one conditions that might be associated with this symptom. It is with this in mind that the subject is presented.

PHYSIOLOGY  The fate of a normal red blood corpuscle seems to be the proper approach to the understanding of icterus. It is recalled that the normal erythrocyte eventually terminates its existence by being broken down in the spleen. In this organ the disintegrated red cell is divided into an iron-containing part (hemosiderin) and

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