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JAMA. 1953;152(6):533. doi:10.1001/jama.1953.03690060049016.
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Physicians are urged through advertisements to prescribe antibiotic troches casually for the treatment of infections of the throat, although in 1949 the Council on Pharmacy and Chemistry omitted from New and Non-official Remedies troches containing penicillin because of numerous instances of relatively severe sensitivity reactions. Effective concentration of the medicament cannot be maintained for long on the surface of the tonsils or of the pharynx because of the continual washing effect of saliva. Actually, it is impossible to render the throat sterile, or even aseptic, except possibly for a short time. While it has been observed that in superficial infections of the throat the local administration of penicillin, aureomycin, oxytetracycline (Terramycin), bacitracin, and other antibiotic and chemotherapeutic agents may be effective, their value as topical agents diminishes when the pathogenic micro-organisms have penetrated deeply into the tissues. Once this deeper infection has occurred, locally applied medicaments in the form of


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