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IMMUNITY TO HUMAN AND PASSAGE POLIOMYELITIS VIRUS

SIMON FLEXNER, M.D.
JAMA. 1932;99(15):1244-1246. doi:10.1001/jama.1932.02740670032009.
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A considerable body of knowledge relating to active immunity to the virus of poliomyelitis has grown up since the condition was first described in 1910.1 This paper will deal briefly2 with several aspects of this immunity problem.

In the first place, attention will be given to the immunity produced in monkeys by the subcutaneous or the intradermal injection of specimens of virus passed through many monkeys or derived immediately from fatal cases of human poliomyelitis. A comparison of the quality of the immunity in the two cases will be made according to the resistance against infection and the demonstration of antiviral or neutralizing properties in the blood serums.

A consideration of this problem leads directly to questions of differences or variants of the virus as it exists in epidemics arising in separate years or in places widely removed from one another, and to changes produced in the human

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