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ATYPICAL TUBERCULIN REACTIONS

L. S. Arany, M.D.
JAMA. 1953;152(6):491-493. doi:10.1001/jama.1953.03690060007003.
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The Mantoux test is considered to be positive if in 48 hours an area of infiltration of at least 5 mm. diameter is present at the site of the intracutaneous injection. There is no definite agreement as to the minimum size of the reaction that is to be considered positive. Some investigators will not call a Mantoux test positive unless the diameter is 10 mm. or more. The reaction, as a rule, persists or even becomes larger in 72 hours, and some physicians prefer to do the reading in 72 rather than in 48 hours. Areas of erythema without induration that appear in 24 hours but fade away in 48 hours are generally considered false positive reactions and are not uncommonly seen when larger doses of old tuberculin or purified protein derivative are used. As far as purified protein derivative is concerned, the specificity of even typical positive tests is

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