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RECURRENCES OF UNDULANT FEVER (BRUCELLOSIS) FOLLOWING THE ADMINISTRATION OF SULFANILAMIDE

W. Turner Bynum, M.D.
JAMA. 1939;112(9):835-836. doi:10.1001/jama.1939.62800090001009.
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Within the past year ten articles in the American and British literature have come to my attention, all reporting uniformly good results in the treatment of undulant fever with sulfanilamide, no case of failure having been recorded. Because of this, and because of the unusually small number of cases reported in any series, along with the danger of the indiscriminate use of this remedy and the belief that a word of warning should be voiced to prevent the overenthusiastic employment of this procedure, I report six cases which have been unsuccessfully treated with large doses of this drug as described in the aforementioned articles:

REPORT OF CASES 

Case 1.—  A white man aged 28 entered the clinic May 3, 1938, complaining of chills, fever, fatigue and aching in the lower part of the back and the calves of both legs.The patient was a dairy worker and stated that it

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