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Abraham Cohen, M.D.; Isadore Rose, M.D.; Edward Cooper, M.D.
JAMA. 1953;152(5):402-403. doi:10.1001/jama.1953.63690050004008b.
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The value of corticotropin (ACTH) and cortisone in rheumatoid arthritis and allied diseases has been well established. The pituitary-adrenal axis relationship has been described by Selye1 and others, and this has been the stimulus for various types of clinical application. Among the chemical agents used in the treatment of rheumatoid

arthritis recently is nitrogen mustard, as reported by Diaz and co-workers.2 Their preliminary report indicated that dramatic results could be expected with nitrogen mustard, and it was felt that further work along this line was indicated. Accordingly, a clinical study was undertaken, and, in addition, detailed laboratory studies were made to determine whether the usual excretion and retention results obtained with corticotropin and cortisone could be obtained.

PLAN OF STUDY  A series of seven patients was treated with nitrogen mustard. Four patients had rheumatoid arthritis, one had mixed arthritis, and the other two had gout. All were hospitalized


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