October 22, 1949, Vol 141, No. 8 >

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LOCALIZING CEREBELLAR SYNDROMES

JOE R. BROWN, M.D.

JAMA. 1949;141(8):518-521. doi:10.1001/jama.1949.02910080018006.

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ABSTRACT

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In 1917 Gordon Holmes¹ published his classic dissertation on cerebellar symptomatology. Despite this work, the localization of cerebellar lesions has continued to be difficult. In recent years greater understanding of the cerebellum has become available through studies of cerebellar morphology and physiology.² These advances have made it possible to recognize localizing syndromes which are of pure cerebellar origin and additional symptom complexes which result from combined involvement of the cerebellum and adjacent structures.³ As a preliminary step to the understanding of these syndromes, it is important to review briefly the recent advances in the clinical aspects of cerebellar anatomy.

No attempt will be made to go into the finer details of cerebellar anatomy, physiology, histology and comparative morphology. Generalizations made for clinical purposes leave inaccuracies as to finer details but are valuable when dealing with patients.

CEREBELLAR ANATOMY The Purkinje cells of the cerebellum are arranged in

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BROWN JR. LOCALIZING CEREBELLAR SYNDROMES. JAMA. 1949;141(8):518-521. doi:10.1001/jama.1949.02910080018006.

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