JAMA. 1953;152(1):70. doi:10.1001/jama.1953.03690010076021.
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Bacteriology of Sinusitis.  — a paper read before the department of otorhinolaryngology of the Associacão Paulista de Medicina, Drs. Augusto de Escragnole Taunney and Mauro Candido de Souza Dias emphasized the frequent occurrence of resistance of acute and chronic infections of the upper respiratory tract to treatment with penicillin and other antibiotics. They discussed experiments that they had performed: A culture was made from the sinus exudate of 45 patients with sinusitis and the nasal mucus of 25 clinically normal persons. The micro-organism found was isolated, identified, and submitted to sensitivity tests to the following antibiotics: penicillin, streptomycin, chloramphenicol, aureomycin, and oxytetracycline ("terramycin"). The sinus exudate was obtained from the sinus cavity in three different ways: by trepanation of the anterior wall, by the puncture of the inferior meatus, and by aspiration of the middle meatus. In the normal patients, the mucus was removed from the middle meatus with a


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