JAMA. 1932;99(13):1086. doi:10.1001/jama.1932.02740650044014.
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The gallbladder, one of the smallest of the abdominal viscera, has been the subject of much interesting investigation. For a long time it was considered a mere passive diverticulum in the biliary tract. Because it was a frequent site of inflammation and often contained gallstones, the interest of pathologists and surgeons was aroused. The concentrating activity as demonstrated by Rous and McMaster in 1921 served to renew interest and initiated a series of investigations, which have been fruitful. While there still may be some dispute, it is generally agreed that this organ has an important motor function in the discharge of bile into the duodenum; that it absorbs, besides water and other substances, calcium and bile salts; that it excretes mucus, and that it makes the bile more acid. Thus it achieved a considerable dignity. It goes without saying that only such knowledge of its physiology can lead to a


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