0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Other Articles |

STREPTOMYCIN RESISTANCE OF GONOCOCCI AND MENINGOCOCCI

C. PHILLIP MILLER, M.D.; MARJORIE BOHNHOFF, B.S.
JAMA. 1946;130(8):485-488. doi:10.1001/jama.1946.02870080019005.
Text Size: A A A
Published online

Drug resistance or "fastness," that is the acquisition by micro-organisms of tolerance for chemotherapeutic agents, has long engaged the attention of bacteriologists and parasitologists1 and has recently become a matter of concern among clinicians and epidemiologists. Resistant strains of micro-organisms usually susceptible to the sulfonamides have been recognized for some time, and penicillin resistant strains are now beginning to appear in clinic and laboratory. The apprehension which might have been caused by the latter is currently being allayed by the introduction of streptomycin.

Experiments which we2 have recently completed have demonstrated that meningococci and gonococci acquire resistance to penicillin during cultivation on mediums containing penicillin, provided its concentration is increased carefully at each transfer and kept below the level which inhibits active multiplication of the micro-organisms. By observing these precautions, the penicillin tolerance of a strain of gonococcus has been raised to a degree which allows it to

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();