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ARTICLE |

Die Permeabilitätspathologie als die Lehre vom Krankheitsbeginn

JAMA. 1949;141(3):235. doi:10.1001/jama.1949.02910030065040.
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ABSTRACT

This book represents a much enlarged edition of the previously published monograph of this author on serous inflammation. Additional observations include studies with fluorescent microscopy, investigations on hepatic diseases derived from experiences during the war and studies on renal diseases. In the original publication, considerable emphasis was placed on the escape of plasma proteins into the tissue spaces and on the sequelae supposedly resulting from this escape. Much importance was attached to this serous inflammation (a name derived from Roessle) in various parenchymal organs. In the present enlarged treatise, in addition, the invasion of the parenchymal cells themselves by plasma proteins is stressed. These shifts in plasma proteins caused by altered permeability of the cellular membranes and capillaries are considered important in the pathogenesis of many diseases. Disturbances of the permeability of cellular and capillary membranes are considered the initial processes of many pathologic conditions. Morphologic and functional alterations in

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