In the past fifteen years, as a result of the studies of Longcope and of Weiss and Parker, there has been wider recognition of the considerable frequency and great clinical importance of chronic pyelonephritis—a condition previously rarely diagnosed during life and often even misinterpreted at necropsy. This first presentation of detailed studies of renal function in chronic pyelonephritis by modern methods is a welcome addition to the literature on the disease, hitherto largely etiologic, anatomic and clinical. Included are systematic measurements of renal blood flow, glomerular filtration, iodopyracet tubular maximum (Tm), self depression and saturation limits for iodopyracet, urea clearance, urinary concentration and plasma protein fractions.
The monograph opens with a description of the results in 202 autopsies in which chronic pyelonephritis was present. Indicative of the frequency of chronic pyelonephritis is the fact that these constituted 5.6 per cent of all autopsies. Uremia was the cause of death in