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Matthew T. Moore, M.D.
JAMA. 1946;130(7):445. doi:10.1001/jama.1946.02870070065023.
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To the Editor:—  Referring to the comment anent the article "Paroxysmal Abdominal Pain" published in the December 29 issue of The Journal, I submit the following::In none of the 6 cases reported was there any specific mention made that a definite allergen was the causative factor which precipitated the attacks of abdominal pain. In the first case it was clearly stated that the author believed "the original injection of diphtheria antitoxin had produced an angioneurotic edema of the brain with subsequent changes in the cerebral cortex which predisposed to abnormal cerebral discharges." This patient had been studied by several prominent allergists, had been given the gamut of the usual tests and had been placed on various diets, all to no avail. Were there a specific allergen operative in the production of this patient's seizures, they certainly would have continued after treatment with anticonvulsants as well as prior to therapy.


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