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DICUMAROL IN ACUTE CORONARY THROMBOSIS

H. RAYMOND PETERS, M.D.; J. ROY GUYTHER, M.D.; CHARLES E. BRAMBEL, Ph.D.
JAMA. 1946;130(7):398-403. doi:10.1001/jama.1946.02870070018005.
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The increasing incidence of coronary thrombosis has been dwelt on frequently in recent medical literature and indeed has at times reached the lay press. The ever present challenge of this disease to the medical therapist might best be brought home to the physician himself when he realizes that approximately one out of five members of his own profession is stricken fatally with coronary thrombosis and occlusion. Thus, recent statistics show that in 1944 this disease accounted for 18 per cent of the deaths of physicians in this country.1

Much has been written on the pathogenesis, diagnosis and therapy of coronary thrombosis. Certainly in more recent years the clinician has had a better knowledge of the pathogenesis. His alertness and ability today to make earlier diagnosis has automatically given more effective treatment. Treatment itself is unfortunately limited by lack of specific therapy. The patient is put to bed, strenuous efforts

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