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September 10, 1949, Vol 141, No. 2 >
ARTICLE | September 10, 1949

THE TREATMENT OF ACUTE TYPHOID FEVER WITH CHLOROMYCETIN®

WILMOT D. FOSTER, M.D.; ROBERT J. CONDON, M.D.
JAMA. 1949;141(2):131-132. doi:10.1001/jama.1949.62910020004006d.
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The antibiotic chloramphenical (chloromycetin®) was first tested clinically against typhoid in the Federation of Malaya last year. The efficacy of the drug against the organism Eberthella typhosa was established by this investigation.1 Chloramphenicol is a crystalline substance obtained through the processes of concentration and purification of cultures in liquid mediums of a species of Streptomyces originally isolated by Burkholder and shown by him to possess antibacterial activity.2 Ehrlich and his associates in the research laboratories of Parke, Davis & Company carried out the studies of the antibiotic activity of this species of Streptomyces which led to the preparation of a compound which was given the name chloromycetin.

The purpose of this report is to further substantiate the observations of Woodward and co-workers.1 The aforementioned investigation was carried out in an endemic typhoid area; this case may be designated as sporadic. It is by nature comparable, however, to

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