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September 10, 1949, Vol 141, No. 2 >
ARTICLE | September 10, 1949

RELATION OF RELAPSES IN TYPHOID TO DURATION OF CHLORAMPHENICOL THERAPY

JOSEPH E. SMADEL, M.D.; THEODORE E. WOODWARD, M.D.; CHARLES A. BAILEY, M.D.
JAMA. 1949;141(2):129. doi:10.1001/jama.1949.62910020002006b.
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During the past year much information has accumulated on the use of chloramphenicol (chloromycetin®) in the treatment of typhoid. This confirms the original report of Woodward and others,1 covering the observations on 10 patients, which clearly indicated that the new antibiotic was of great value in this disease. Continued experience reveals that fever disappears by lysis during the first three or four days of treatment.

Our early observations,1 as well as those of McDermott and his associates,2 brought out that relapses of typhoid were common in treated patients. In order to eliminate such occurrences, we have prolonged the course of treatment in persons infected with Salmonella typhosa. Analysis of the results obtained in 44 patients with typhoid who received chloramphenicol therapeutically under our observation has indicated a striking relation between the duration of chemotherapy and the incidence of relapses.

Although our observations are being reported in detail

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