Other Articles |

TREATMENT OF MIXED INFECTIONS WITH PENICILLIN:  I. With Special Reference to the Adjuvant Action of Parachlorophenol

JAMA. 1946;130(3):121-124. doi:10.1001/jama.1946.02870030001001.
Text Size: A A A
Published online

In the course of our study of established infections during the past year and a half, it has been demonstrated frequently that penicillin is of questionable benefit or no benefit at all in the treatment of many infections in which there is a mixture of organisms. In some of these infections there is undoubtedly a synergistic action on the part of the bacteria in the production of the pathologic process. In other cases, secondary contaminants which are not pathogenic or are only feebly so, under ordinary circumstances, are able to multiply in the presence of wound exudate or dead tissue.

Using the wound as a culture medium, these organisms produce metabolic products which may be toxic locally to the tissues of the wound or may be absorbed by the body and give rise to general symptoms. Certain of these metabolic products may also destroy the growth-inhibiting action of penicillin. Abraham


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.