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Essai de traitement de la migraine et de l'épilepsie par les solutions hypertoniques: Etude clinique et expérimentale

JAMA. 1938;111(27):2513-2514. doi:10.1001/jama.1938.02790530067034.
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From reading the first part of this work, one may deduce that the author, more in desperation than anything else, treated a patient who had severe migraine and epileptic equivalents with a 20 per cent solution of sodium chloride and bromide and observed considerable relief in symptoms. Thereupon he applied this method of treatment to thirty-five epileptic and seven migrainous patients, experimenting a little with different methods of administration and also with magnesium sulfate. Finally he seems to have hunted around for a possible explanation of the effects observed. He found this medication (sodium chloride 2 Gm., sodium bromide 2 Gm., sterile dis-dis tilled water 20 cc.) most effective in cases of status. By practicing the injections three times a week he was able to reduce the frequency of both the epileptic and the migrainous attacks. The author's principal experimental work was the observation of the fall in cerebrospinal fluid


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