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JAMA. 1938;111(26):2345-2351. doi:10.1001/jama.1938.02790520001001.
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Many factors that enter into the problem of the initiation of allergy have been considered in a previous paper of this series in which the various modes of acquisition were treated.1 Here attention will be directed mainly to certain observations relative to the early beginnings and the natural course that allergy follows with increasing age. I have limited my observations to the four major syndromes eczema, asthma, hay fever and urticaria. A correlation of such observations, I believe, will help in the early diagnosis of these conditions and, if properly treated, should tend to abort further progress of the allergic syndromes.

THE ONSET  Practically all students concerned with allergy in adults find that from 50 to 60 per cent of their patients give a history of onset in childhood. The early careful observations of the beginnings of allergy, however, were first made by pediatricians, among whom should be mentioned


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