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Eine experimentelle Studie über Calciumoxalat als Steinbildner in den Harnwegen: Speziell mit Rücksicht auf die Bedeutung des Magnesiums

JAMA. 1938;111(21):1957-1958. doi:10.1001/jama.1938.02790470069031.
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This is a monograph in which the role of calcium oxalate in relation to stone formation in the urinary tract is exhaustively studied. Many tables are presented in demonstrating the physical properties of calcium oxalate in relation to solubility. The various effects of magnesium intake and urinary magnesium excretion on the formation of calcium oxalate stones are forcefully stressed. In animal experiments using rats, stone formation was frequent when the urinary magnesium excretion was lowered with coincidental increased calcium and oxalic acid excretion. However, if vitamin A and D deficiency was added to the foregoing conditions, stone formation was still greater and damage to the renal parenchyma more marked. An acid producing diet reduced definitely the incidence of stone formation. The frequency of stone formation in a large series of animals was greater in the male, coinciding with a higher urinary calcium output in the male sex. Males showed in


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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