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SULFANILAMIDE IN THE TREATMENT OF BRAIN ABSCESS AND PREVENTION OF MENINGITIS

PAUL C. BUCY, M.D.
JAMA. 1938;111(18):1639-1641. doi:10.1001/jama.1938.02790440033007.
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The cure of a brain abscess and prevention of an almost certain hemolytic streptococcus meningitis by the administration of sulfanilamide has not been previously reported. Rowe1 in a recent article describes two cases of brain abscess in which sulfanilamide constituted part of the therapy. The first patient had a pneumococcic (type V) abscess of the cerebellum which was treated also by surgical drainage and the administration of 220,000 units of appropriate pneumococcus antiserum. The second patient had a cerebellar abscess, culture of which revealed Friedländer's bacillus. The abscess was also treated by surgical drainage. As many instances of abscesses similar to these cured by drainage alone are known, as pneumococcus antiserum was used in case 1 and as sulfanilamide has not been shown to be effective against Friedländer's bacillus, as Rowe notes, it is impossible to credit sulfanilamide with the excellent result obtained in Rowe's cases.

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