0
October 15, 1938, Vol 111, No. 16 >
Other Articles | October 15, 1938

THE CHEMISTRY OF VITAMIN C

C. G. KING, Ph.D.
JAMA. 1938;111(16):1462-1464. doi:10.1001/jama.1938.72790420004012.
Text Size: A A A
Published online
Article
References

IDENTIFICATION  A primary requisite for studying the chemical nature of vitamin C was provided by Hoist and Frölich1 when they observed that the guinea pig could be used as an experimental animal for the study of scurvy. The experimental diets and general technic developed by Cohen and Mendel2 and La Mer, Campbell and Sherman3 then made it possible to measure antiscorbutic activity in a satisfactory quantitative manner, free from interference by deficiencies in other essential nutrients. Attempts to isolate the vitamin from natural products encountered great difficulty, however, because of its extreme sensitiveness to destruction by oxidation.By 1931 many investigators, particularly Zilva and his associates,4 Bezssonoff and his associates5 and King and his associates6 had succeeded in concentrating the vitamin to such a degree that approximately 1 to 2 mg. of solids daily served to protect young guinea pigs from scurvy. The isolation

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

References

Letters

Submit a Letter
CME
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Clear Answers | Save For Later
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs

More Listings at
JAMACareerCenter.com >

© 2013 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems