Other Articles |


JAMA. 1938;111(16):1455-1456. doi:10.1001/jama.1938.02790420035008.
Text Size: A A A
Published online

The relation between the spleen and the contents of platelets in circulating blood have for a long time now been admitted on purely clinical and empirical bases (therapeutic action of splenectomy in Werlhof's disease, thrombopenia secondary to primitive splenomegaly). Some series of researches carried out in the last few years seem to allow an experimental framing of this relationship and an interpretation of its nature.

In 1933 a series of researches on the subject was begun in the laboratory of this clinic. We1 were able to establish that extracts of spleen taken from patients affected by Werlhof's disease applied in highly concentrated doses injure the megakaryocytes in cultures in vitro of the bone marrow of guinea pigs. The extraction was performed with the technic used in extracting trephones and therefore contained the whole hydrosoluble fraction dissolved, and the other fractions were suspended or in emulsion. So up to a


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.