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JAMA. 1932;99(7):575. doi:10.1001/jama.1932.02740590055025.
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Cyanosis Caused by Alveolar Hypoventilation  Dr. B. A. Houssay recently delivered a lecture before the Academia Nacional de Medicina of Buenos Aires on insufficient oxygenation of the arterial blood in patients with Ayerza's disease. Ayerza described, using the term "black cardiac patients," a certain type of patients with chronic bronchial or emphysematous disturbances, who present a clinical picture of cyanosis associated with an increase in the red blood cells, somnolence and other symptoms. Because of the cyanosis, the patients seem to be suffering from cardiac decompensation although they really are not. Later the cardiac insufficiency appears and the cyanosis increases. The speaker and his assistant Dr. I. Berconsky have observed several cases of Ayerza's disease at the Instituto de Fisiología of Buenos Aires. In all cases arterial cyanosis was present. The hemoglobin of the blood had an oxygen saturation of from 75 to 85 per cent of its volume instead


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