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JAMA. 1938;111(6):489-492. doi:10.1001/jama.1938.02790320001001.
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The treatment of carcinoma of the breast consists essentially of (1) the prevention, if possible, of its occurrence, (2) the removal of the malignant growth from the chest wall in such a manner that local recurrences will be decreased or altogether eliminated, and (3) the proper handling of the patient after the carcinoma has extended beyond the chest wall.

PROPHYLAXIS  As the cause of cancer is unknown, a discussion of its prevention must necessarily deal with unknown factors. However, a close observation of more than 500 cases of carcinoma of the breast during a quarter of a century does yield some suggestions. While these suggestions might not be helpful in preventing carcinoma, they at least may be applied to add to the well being of the patient.Patients with painful breasts associated with menstruation often obtain relief from the hypodermic employment of an estrogenic substance started a few days before


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