Fluorine apparently has an influence on the thyroid, but there is no agreement as to just how the gland is affected and how this effect is manifested. Houssay1 produced goiter in two white rats by giving them water from the goitrous region of Cerrillos, Argentina. This water is reported to contain fluorine. Goldemberg2 produced a condition in rats which resembled cretinism by the administration of sodium fluoride. The thyroids of these rats were from five to six times as large as those of normal rats. Tolle and Maynard3 and Kick and his associates4 on the other hand could detect no enlargement of the thyroids of rats on different levels of fluorine for varying lengths of time.
Cristiani5 observed marked lesions in the thyroids of guinea pigs dying from chronic fluorine intoxication. Phillips and Lamb6 observed a mild parenchymatous proliferation in the thyroids of rats