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JAMA. 1938;110(26):2156. doi:10.1001/jama.1938.02790260030012.
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In the past it has been presumed by some immunologists that the fixed tissues are autonomous in production of specific antibodies. Recent investigations indicate, however, that antibody production is further dependent on unknown hormonal or neurologic integrations.

Scores of unsuccessful attempts have been made to produce specific antibodies by adding antigens to tissue cultures. In spite of the few allegedly successful results the general consensus is that explants from the spleen, lungs and bone marrow of embryonic or adult laboratory animals are incapable of synthesizing precipitins, agglutinins, hemolysins, antitoxins or complement-deviating antibodies.1

Admitting these failures, recent investigators have modified the in vitro technic. They have injected antigens intravenously into experimental animals and after arbitrary intervals made tissue cultures from antigenladen spleen or bone marrow. Landsteiner and Parker2 of the Rockefeller Institute, for example, found that antigen-laden splenic fragments taken from rabbits injected from one to twenty-four hours previously


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