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JAMA. 1938;110(19):1609. doi:10.1001/jama.1938.02790190079012.
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Xanthomatosis has for many years been a condition of obscure etiology. Most observers agree that the syndrome xanthomatosis is a manifestation of disturbed lipoid metabolism. Many unsolved questions remain with regard to the lipoid metabolism itself and its relation to the general metabolism. No doubt xanthomatosis includes a number of heretofore unrelated clinical conditions. First it was described as a rare disease of the skin. The commonly seen lesion is the familiar orange-yellow plaque on the eyelids of persons past middle life. The lesions are not confined to the skin but are observed in connection with tendon sheaths, mucous membranes, the heart, the peritoneum, the liver, the spleen and other internal organs. The lesions appear as plaques or nodules of a striking sulfur yellow to yellow-brown. The characteristic microscopic feature is the presence of large bright polyhedral cells with vacuolated or "foamy" protoplasm due to the high content of a


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