0
Other Articles |

SERUM-POTENTIATED TUBERCULOSIS VACCINE

JAMA. 1938;110(13):1050-1051. doi:10.1001/jama.1938.02790130110013.
Text Size: A A A
Published online

The history of vaccine therapy in tuberculosis has been characterized by repeated claims of success in laboratory animals followed by demonstrated clinical failure. Nevertheless the search goes on, the most recent being heat-killed suspension of tubercle bacilli energized with horse serum. According to Opie and Freund,1 this energized vaccine is as effective as the Calmette-Guérin viable vaccine (BCG) when used as a prophylactic agent in tuberculosis.

About four years ago a new direction was given to vaccine research by the discovery of the "Burky phenomenon,"2 the possibility of rendering certain relatively nonantigenic substances highly antigenic by combining them with "synergins" or "potentiators." Burky found that staphylococcus toxin, for example, will energize pollen proteins or homologous lens proteins in such a way as to render them highly antigenic for rabbits. This observation has been confirmed by Swift and Schultz3 of the Rockefeller Institute, who have found that substances

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();