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Eugene Ziskind, M.D.
JAMA. 1938;110(12):915. doi:10.1001/jama.1938.02790120057020.
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To the Editor:—  Cameron and Hoskins (The Journal, Oct. 16, 1937, p. 1246) say "we consider that when convulsions occur treatment should be terminated immediately by means of intravenous sugar." Epileptiform attacks during the course of insulin treatment in schizophrenia have occasioned various reactions among different investigators. Sakel himself stated that he tried to avoid convulsions. Rymer, Benjamin and Ebaugh (The Journal, Oct. 16, 1937, p. 1249) state that their results indicate that "convulsions did not interfere with good therapeutic results." Wortis (The Journal, Oct. 30, 1937, p. 1470) writes that "some recognize convulsions as not only harmless but even beneficial." He also points out that although Sakel considers the convulsive reactions as "heavy artillery" and prefers to use "light artillery," nevertheless he recognizes that favorable effects sometimes follow major seizures. On the whole the actual status of convulsive reactions in the treatment is still uncertain.Successes with the convulsant


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