JAMA. 1932;98(21):1826-1827. doi:10.1001/jama.1932.02730470048023.
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Observations on Bromine in the Blood of Mental Patients  Prof. H. Zondek announced in an address delivered before the Berliner Medizinische Gesellschaft that he believes that he has found new and promising ways of treating certain mental diseases. Through skilful combination of chemical, physiologic, anatomic and clinical observations, Zondek became convinced that changes in the bromine content of human blood play a part in cyclic insanity or in manic-depressive conditions. In such cases, he found a considerable diminution of the bromine content of the blood. He successfully treated forty cases of melancholia with small quantities of bromine. This remarkable announcement awakened great interest. Zondek stated that he discovered in the hypophysis a bromine-containing hormone, from which he produced a preparation soluble in water. In experiments on the dog, one can reduce the motor power with this hormone and induce fatigue and apathy. The manner in which this hormone acts on


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