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Hosea W. McAdoo, M.D.
JAMA. 1938;110(7):528. doi:10.1001/jama.1938.02790070052024.
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To the Editor:—  In connection with the metrazol convulsive treatment of schizophrenia we recently encountered a phenomenon to which I think attention should be called.Ordinarily we expect the metrazol reaction to occur within less time than a minute after injection with the drug. In our experience the onset is usually from fifteen to twenty seconds later. We recently had a young man who was given a unit dose of 3 cc., to which he responded with fixed expression and staring lasting a matter of a few seconds, a fairly typical petit mal reaction from which he recovered as usual. At the time of the next treatment he was given 4 cc. of metrazol with even less reaction. On the third treatment he was given 5 cc. There was no question whatever about the drug being in the vein. In approximately fifteen seconds he showed an exceedingly mild clonic convulsion,


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