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Leo H. Criep, M.D.
JAMA. 1938;110(7):506-508. doi:10.1001/jama.1938.62790070001008.
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Allergy to liver extract acquired as a result of injections received for the treatment of pernicious anemia is reported in American literature only twice. The report by Metzger1 describes an asthmatic reaction following administration of liver extract. The second report, by Held and Goldbloom,2 describes the development of urticaria, which is thought to be due to the accumulation of uric acid. No studies were carried out in these two cases to determine the nature of the immunologic response involved in this type of sensitivity.

Four reports appear in the foreign literature. Roovers3 reports several instances in which asthma, urticaria and other unpleasant reactions developed in patients receiving liver extract by injection. Engel4 describes a reaction consisting of marked weakness, imperceptible pulse, vomiting and a skin rash immediately after an injection of liver extract in a patient who had been receiving liver by injection for a period


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