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George Zippert, M.D.
JAMA. 1938;110(1):64. doi:10.1001/jama.1938.02790010066020.
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To the Editor.—  In Queries and Minor Notes in The Journal, November 13, page 1659, the "interferometric blood examination" is designated as "sheer nonsense or worse." The method in question is that employed by Abderhalden for the determination of protective ferments in blood serum. In view of the diagnostic possibilities and the insight into endocrine correlations that may be gained by using Abderhalden's method, this unjustified criticism calls for clarification.Abderhalden's reaction takes advantage of the fact that the presence of foreign proteins in the blood gives rise to the appearance of specific proteolytic ferments, so-called protective ferments (abwehrfermente). Recent further investigations by Abderhalden and his co-workers have furnished evidence that not only ferments against foreign proteins are elaborated by the organism but also ferments against its own proteins, and, what is more striking, against substances that are completely free from protein, as for instance hormones.The products that are


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