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NICOTINIC ACID AND VITAMIN B

Casimir Funk
JAMA. 1937;109(25):2086. doi:10.1001/jama.1937.02780510060023.
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ABSTRACT

To the Editor:—  In The Journal, October 9, page 1203, you had an editorial entitled "The Relation of Nicotinic Acid to Human Pellagra." It was with a sense of pleasure that I found that in describing the recent important developments in this field you referred to work of mine, carried out some twenty-five years ago, which dealt with the isolation (and the significance) of nicotinic acid, as obtained from the vitamin B complex.You state that "Funk demonstrated that nicotinic acid is a constituent of the naturally occurring vitamin B complex, even though he had apparently assigned the wrong physiologic function to his compound." This statement is incorrect; and I would like, with your kind permission, to present the facts.The first attempts to isolate vitamin Bi were made during 1911-1912. The process of fractionation, using yeast and rice polishings, was repeated on a larger scale in 1912, and the

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