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David T. Smith, M.D.; Julian M. Ruffin, M.D.; Susan Gower Smith, M.A.
JAMA. 1937;109(25):2054-2055. doi:10.1001/jama.1937.92780510001008.
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It is well known that liver and certain of its extracts are highly effective in the treatment of canine blacktongue and human pellagra. Recently, Mueller1 and Subba Row2 have isolated nicotinic acid from liver. Elvehjem and his associates3 isolated nicotinic acid amide from liver and showed that pure nicotinic acid (Eastman) would cure experimental blacktongue. This observation has been confirmed by Dann4 and by Margolis and his co-workers.5 The latter found that nicotinic acid in doses of 1.5 mg. per kilogram of body weight was highly effective in curing blacktongue in dogs, and harmless, whether administered orally, intramuscularly or intravenously. We have recently had the opportunity of using nicotinic acid in the treatment of a man with a very severe case of pellagra, with results so satisfactory that we feel that the case should he recorded.

REPORT OF CASE  W. H. B., a white male farmer, aged 42, weighing


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