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THE TREATMENT OF MENORRHAGIA AND METRORRHAGIA BY ENDOCRINE PRODUCTS

JOHN C. BURCH, M.D.; G. S. McCLELLAN, M.D.; JOHN W. SIMPSON, M.D.; CLAUD D. JOHNSON, M.D.; E. T. ELLISON, M.D.
JAMA. 1937;109(23):1869-1871. doi:10.1001/jama.1937.02780490007002.
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Menorrhagia and metrorrhagia are among the most interesting complaints confronting the gynecologist. They result from a variety of both organic and functional diseases. In the latter, endocrine products are useful; in the former, they have no place. In any discussion of the treatment of abnormal uterine bleeding, one must remember that bleeding is only a symptom and that it can result from various causes. An adequate diagnosis is a prerequisite to rational therapy. It is our purpose in this paper to present certain observations concerning the etiology of functional uterine bleeding and the rôle of endocrine products in the treatment of menorrhagia and metrorrhagia.

Two lines of study have contributed to this progress. On the one hand, a combination of clinical and pathologic observations has established the relationship of the symptoms to the microscopic appearance of the endometrium. On the other hand, the experimental reproduction of the endometrial changes has

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