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TRYPARSAMIDE THERAPY OF NEUROSYPHILIS AND ATROPHY OF THE OPTIC NERVE

LEO L. MAYER, M.D.
JAMA. 1937;109(22):1793-1796. doi:10.1001/jama.1937.02780480025006.
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It has been fifteen years since the first injection of tryparsamide was given for syphilis of the central nervous system.1 The frequency of involvement of the optic nerve in neurosyphilis prompted an early report on the visual disturbances produced by tryparsamide.2 It seems fitting at this time to reconsider and reflect on the conclusions of these early reports by means of a study covering a ten year period, during which time a relatively large and varied group of patients were observed as to the end results obtained. Three clinics in the Chicago area were chosen for this report: the Mandel Clinic of the Michael Reese Hospital, the Eye Clinic of the Northwestern University Medical School and the Syphilis Department of the Public Health Institute. An attempt was made to review the progress of every patient treated with tryparsamide after it became available. For the past seven years I

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