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METRAZOL VERSUS INSULIN IN THE TREATMENT OF SCHIZOPHRENIA

Joseph Wortis, M.D.
JAMA. 1937;109(18):1470. doi:10.1001/jama.1937.02780440060025.
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ABSTRACT

To the Editor:—  With the hypoglycemic insulin and metrazol convulsant therapies of schizophrenia both already introduced into this country, the rivalry between the two forms of treatment that has already broken out in Europe will soon be carried to these shores. Physicians will be particularly interested in the effect of the controversy on actual therapeutic procedure.The shock treatment was introduced by Sakel at a meeting of the Gesellschaft der Aerzte in Vienna, Nov. 3, 1933. The official report of the society proceedings may be read in the Wiener klinische Wochenschrift for Nov. 10, 1933. It is stated (page 1372) that the insulin shock treatment consists of the production of severe hypoglycemic shock with coma and epileptic seizures ("Erzeugung von schweren hypoglykämischen Shocks, eventuell mit Koma und epileptischen Anfällen durch hohe Insulindosen"). In the ensuing discussion, Prof. Otto Poetzl, chief of the Psychiatric University Clinic, under whose supervision the work

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