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William B. Wendel, Ph.D.
JAMA. 1937;109(15):1216. doi:10.1001/jama.1937.02780410054018.
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To the Editor:—  In 1933 Williams and Challis (J. Lab. & Clin. Med.19:166 [Nov.] 1933) reported that methylene blue was effective as an antidote for parabromaniline poisoning. Shortly afterward Steele and Spink (New England J. Med.208:1152 [June] 1933) used methylene blue in a case of aniline poisoning and also in one of acetanilid poisoning, with what they considered dramatic recoveries. Both groups of workers stated that the methemoglobinemia shown by their patients before administration of methylene blue rapidly disappeared following intravenous injection of the dye. Williams and Challis, subsequent to treatment of their patient, carried out experiments on rabbits, the results of which they considered as justification for their claim that methylene blue had been responsible for the rapid improvement of their patient. Little attention appears to have been paid these observations and the writers themselves have not commented further in the literature on what, if


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